Research and Development (R&D)
MARDI
PhytoChemical Constituents

5,7-dimethoxyflavone


Research in Mardi shows that black ginger extract appears to be ‘healthy’ and a good source of a class of Bioflavonoids compounds with methoxy groups added to them, known as methoxyflavones. The bioactive component are consisting of 5,7-dimethoxyflavone, 5-hydroxy-3,7,4′-trimethoxyflavone and 5- hydroxy-3,7-dimethoxyflavone and almost major flavones compounds.


5-hydroxy-3,7,4′-trimethoxyflavone


Quality Control and production of the bioflavonoid in MARDI

Black ginger contains flavonoids and flavonoid glycosides that bear many methoxyl groups and chalcone derivatives. Among the flavonoids, 5,7-dimethoxyflavone and 5,7,4 trimethoxyflavone and 5,7,3,4-tetramethoxyflavone the higher phytonutrient content in black ginger. 5,7-dimethoxyflavone is the flavones which are used for standardization of crude extract by LCMS fingerprints for control a quality.




1. Bioflavonoid rich – Black G Coffee

2. Bioflavonoid rich – Black G Capsules

Dosage and Safety

  • Maximum dose of 400mg per day. 1 capsule daily during empty stomach

3. Bioflavonoid rich – Black Ginger Plus Liquid & EnerGplus

100% pure, natural, no chemicals, no stimulants.
Premium product, premium quality, all natural ingredients.


Each 1000mg dried powder extract have 8.0mg 5,7 dimethoxyflavone


Toxicity and efficacy

ASSESSMENT OF KAEMPFERIA PARVIFLORA

Benefits of black ginger
• Excellent antioxidant (endogenous antioxidant)
• Reduce the risk of muscle pain, headache/stomach, enhance muscle strength, improves the blood
supply to the muscle cells.
• Can help to balance hormone levels, regulate menstrual periods and increase wellbeing for women, however, results may vary depending on the individual.
• Aphrodisiac activity (enhance sexual desire, sexual motivation and sexual performance)
• Antiplasmodial (prevent of malaria or dengue) antifungal and mild antimycobacterial
• Adaptogenic activity and antidepressant effects (increase resistance to a broad spectrum of harmful factors (stressors) of different physical, chemical and biological natures)
• Inflammatory-related diseases: gout, allergy, aphthous ulcer and peptic ulcer.
• Anti-allergic activity
• Anti-gastric ulcer effect
• Anti-obesity effects
• Preventing diabetes, lower blood glucose levels
• Improve blood flow
• Anticholinesterase activity (prevents and cures Alzheimer’s disease)
• Regulate blood sugar and blood circulation, Increases blood circulation
• Increases libido, lust
• Improves endurance and vitality
• Increases strength and energy, reduces fatigue
• Helps the digestive system
• Reducing triglycerides,
• Anti-metabolic syndrome effect
• Recovery of excessive cold sensitivity and swelling


Improves the overall quality of your health and well being

Regular consumption of black ginger has shown very positive results, and when administered at
sufficient dosage over a few days, remarkable results can be observed.


Works within 30-60 minutes, lasts for up to 24 hours



WHY BIOFLAVONOID-RICH BLACK GINGER MUST BE INCLUDED IN YOUR DIET

Kaempferia Parviflora (Black ginger ) is a herb that has some historical and medicinal usage for treating metabolic ailments and improving vitality in Thailand and limited to surrounding regions. It is also reported to be an aphrodisiac compound and physical enhancer. Black ginger is a good source of a class of Bioflavonoids compounds with methoxy groups added to them, known as methoxyflavones and anthocyanidins

BioFlavonoids are pigments that produce yellow or red-blue colouring in plants. Along with colour, they provide plants with protection from attacks from insects, fungi and microbes. They’re also linked to cancer and cardiovascular disease prevention. While flavonoids are abundant in many plant foods, intensely coloured foods tend to contain higher amounts. BioFlavonoids are polyphenolic plant pigments widely present in the plant. Lesser known than vitamin C and E, these are a group of antioxidants that are lately receiving a lot of attention for their health benefits.

BioFlavonoids are especially known for their antioxidant activities, which play a significant role in cardiovascular health and in the prevention of cancer. Other than fighting free radicals, they are also known for their antihistamine, antimicrobial, memory enhancing and even mood-boosting properties. BioFlavonoids have gained importance recently because of their tremendous health benefits which include having antitumor, antiplatelet, anti-allergic, anti-inflammatory and anti-oxidant properties. Some of the flavonoids can also be used for the treatment of cuts, bruises, contusions and sprains. These groups of flavonoids are classified as bioflavonoids. Flavonoids are super-antioxidants that support and strengthen cells.

Bioflavonoids found in your favourite healthy foods help to combat heart problems, atherosclerosis, and conditions like Alzheimer’s disease and even cancer.

Bioflavonoid is water soluble, which means that any excess is excreted in urine. The body cannot produce this nutrient and must get it from the diet regularly. Adding herbs to your meals is an excellent way to consume more bioflavonoids.


WHY ARE BIOFLAVONOIDS SO GOOD?

Antioxidants
Flavonoids are anti-­aging, protect your cells from free radicals that increase your risk of heart disease, obesity, diabetes, and prevent many chronic/lifestyle diseases.

Anti-­inflammatory
Bioflavonoids reduce arterial inflammation and adhesion molecules that cause plaque buildup in the arteries. Flavonoids decrease your risk for heart disease, especially atherosclerosis—the hardening of the arteries.

The potential for killing cancer cells
The flavonoids act by inhibiting an important enzyme. However, the researchers said that the trick seemed to be in using the flavonoids as a pre-treatment instead of using them and the chemotherapeutic drug simultaneously, since ‘flavonoids can act as antioxidants and taking antioxidant supplements on the same day as chemotherapeutic drugs may negate the effect of those drugs’.

Cardiovascular benefits
A review study published confirmed on benefits of flavonoids on cardiovascular health. The researchers found that bioflavonoid can reduce blood pressure and had significant effects on LDL and HDL cholesterol.

Beneficial in controlling diabetes
The study also found that insulin resistance was improved by chocolate or cocoa due to significant reductions in serum insulin.

Ease menopausal symptoms
Bioflavonoid has been found to reduce hot flash frequency in perimenopausal and postmenopausal women.

Reduce the risk of osteoporosis
Researchers also found that bioflavonoid may prevent postmenopausal osteoporosis and improve bone strength, thus decreasing the risk of fracture in menopausal women by significantly increased bone mineral density.

Beneficial in rheumatoid arthritis
Bioflavonoid (Proanthocyanidin extract) acting as an antioxidant has a therapeutic effect on collagen-induced arthritis, say the researchers at The Rheumatism Research Center, The Catholic University of Korea, Seoul. They experimented on lab animals and found that GSPE significantly reduced hydrogen peroxide production that destroyed collagen. The researchers also suggested that GSPE may be beneficial for the treatment of chronic autoimmune inflammation, which is commonly observed in rheumatoid arthritis.

Prevent gum disease
The anti-inflammatory activity of bioflavonoid (proanthocyanidins) could effectively inhibit the invasiveness of the gum disease-causing bacteria. Proanthocyanidins can not only prevent gum diseases but may be used to treat the disease as well.

Flavonoids improve cognition in older adults
The flavonoid antioxidants, especially anthocyanidins, have shown to improve cognition in experimental studies. Greater intakes of blueberries and strawberries were associated with slower rates of cognitive decline, according to the Harvard researchers. They also pointed out that ‘berry intake appears to delay cognitive ageing by up to 2.5 years’. Incidentally, flavonoids also reduce the slowing of body movements, fatigue, irritability, and depression, all associated with free radical damage.

Could help control psoriasis flares
May be able to stop psoriasis flares before they even start. Discovered that methoxyluteolin found in black ginger could block mast cells and was an even more potent mast cell blocker. Methoxyluteolin inhibited the ability of mast cells to start inflammation, and could even block inflammation when given before a trigger sets mast cells into action. A study, funded in part by the National Psoriasis Foundation and the National Institutes of Health, discovered that a natural molecule known as methoxyluteolin can block a type of immune cell called mast cells from launching an inflammatory response. Mast cells are the “universal alarm cell” that starts the inflammatory cascade leading to psoriasis. They can be triggered by infection, allergens, environmental factors like pollution, or even emotional stress. Once that happens, mast cells set into motion a series of inflammatory reactions, including the activation of immune cells and the release of tumour necrosis factor-alpha (TNF-alpha), a pro-inflammatory protein, or cytokine, involved in psoriatic disease.

Other benefits of flavonoids
Flavonoids have tremendous benefits because they contain considerable amounts of antioxidants, which are responsible for preventing cell damage and the ageing process in the human body which is caused by free radical reaction. They block UV radiation which is destructive to nucleic acid. Flavonoids may be used in the treatment and prevention of some of the following common diseases: Asthma, Allergies, Atopic Dermatitis, Cataracts, Gout, Muscular Degeneration, Migraines, Stomach Ulcers, Varicose Veins and Heart Disease

No toxicity effects proof
R&D in Mardi show interestingly, there is no evidence of side effects associated with dietary intake of flavonoids –rich black ginger extract. The reason could be attributed to their low bioavailability, that is, poor absorption and quick elimination. However, flavonoids in the supplement form do have side effects, and sometimes severe ones. For example, they can cause nausea, headache, or tingling of the extremities in some people when taken in doses of 1000mg per day. Similarly, a study showed that tea extracts supplement can cause liver toxicity in some cancer patients. Sometimes for those never take herb show underarm sweating and increased body temperature. More serious side effects on high doses include heartbeat speeding and arrhythmia or irregular heart rhythm. This limits the usefulness of this herb in high doses, which a person excessively use more easily show up underarm sweating and increased body temperature

Mechanism of action
The mechanism of action for each group of flavonoids is quite complex in nature. The basic functions of these flavonoids are to help prevent cell damage from the reactive species like peroxynitriles, superoxides, hydroxyl radicals, peroxyl radicals and singlet oxygen. A phenomenon called “oxidative stress”, which eventually leads to cell damage usually occurs in the human body due to an imbalance created between the reactive species (mentioned above) and the antioxidants available in our body from natural food intake. Oxidative stress is harmful as it may cause many diseases like aging, arteriosclerosis, ischemic injury, inflammation of tissues, neurodegenerative diseases like Parkinson’s and Alzheimer’s, including deadly diseases like cancer. All flavonoids, along with enzymes and vitamins in combination, can prevent many diseases in the human body. Studies have shown that daily intake of large amounts of flavonoids are inversely related to the various coronary diseases including heart attacks.

Scientific Support & Reference Citations

Journal of Ethnopharmacologicalcommunication. Anti-allergy activity of compound from kaempferia parviflora. (2008). 116: 191-193
Journal of Pharmaceutical Sciences. Effects of Kaempferia Parviflora Extracts and Their Flavone Constituents on Pglycoprotein Function. (2007) 96(1): 223–233
Journal Food Chemistry. Anti-inflammatory effects of compounds from Kaempferia parviflora and Boesenbergia pandurata. Volume 115, Issue 2, 15 July 2009, Pages 534–538
Journal of Fitoterapia. Bioactive flavonoids from Kaempferia parviflora (2004).75(1):89-92.
The Journal of the Society of Reproduction and Fertility. Effects of Kaempferia parviflora extracts on reproductive parameters and spermatic blood flow in male rats (2008) 136(4): 512-522
American Journal of Agricultural and Biological Sciences. Aphrodisiac activity of Kaempferia parviflora.. (2012). 7(2):114-120
American Journal of Pharmacology and Toxicology. Anti-­‐Stress Effects Of Kaempferia
Parviflora In Immobilization Subjected Rats. (2013)., 8 (1): 31-­‐38.
Journal Photodermatology, Photoimmunology & Photomedicine. The protective effect of Kaempferia parviflora extract on UVB-­‐induced skin photoaging in hairless mice (2014). 30(5):237-­‐245